Due to their small size and unique optical properties, nanoparticles are commonly used to image nanoscale features of inorganic and biological substances. Including the components of cells, structure of tissues, and the transport of molecules. Imaging reagents typically include a reporter which allows the label to be detected and a targeting surface that directs the label to the target. Ideally, the labeling is sensitive and specific so that a complete and accurate visualization of the investigated structure can be obtained.
Plasmonic nanoparticles can be engineered to have very high scattering cross sections that allow sub-100 nm diameter particles to be easily detected with a standard dark field microscope. Multiplexed imaging is accomplished by using plasmonic nanoparticles with different colors due to their material, size and shape. Nanoparticles can also be fluorescently labelled and this fluorescence can be enhanced by using a plasmonic particle that functions as a nanoscale antenna for increasing the fluorescent brightness. Many other nanoparticle imaging formats are also utilized, including Raman labels that provide a unique fingerprint for highly multiplexed imaging applications and magnetic nanoparticles that have high contrast for MRI scans.
NanoComposix has the world’s largest library of plasmonic nanoparticles that can all be functionalized with targeting ligands to function as ultra-bright dark field labels, surface enhanced Raman scatterers, or as an antenna for surface enhanced fluorescent spectroscopy. We also integrate other fluorescent entities into more complex nanocomposite structures including quantum dots, fluorescent polymers, and rare earth fluorophores. Our lateral flow projects use a variety of plasmonic nanoparticles as high contrast absorbers to produce colored lines on test strips. Targeting of all of our materials is accomplished through antibody, DNA, or aptamer binding on the particle surface.
Product Line | Description | Available Materials | Available Surfaces | CV | Concentration | Available Dried | Buy | nanoComposix University |
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Guaranteed low endotoxin | Gold, silver, platinum, magnetite | Multiple | < 18% | 1 mg/mL | No | See products | Learn more | |
For bioconjugation (lateral flow assays, etc.) | Gold | Multiple | < 15% | Varies; usually 20 OD | Yes | See products | Learn more | |
Widest combination of materials and surfaces | Gold, silver, silica, platinum, magnetite | Multiple | Varies; usually < 15% | Varies | Yes | See products | Learn more | |
Most monodisperse | Gold | PEG-carboxyl | < 5% | 0.05 mg/mL | No | See products | Learn more | |
Do none of these work for you? Request a Custom Nanomaterial | ||||||||
We also offer a variety of nanoparticle characterization services |
Surface | Charge | Characteristics | Available Materials | Buy | NCX University |
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Bare (Citrate) | Easiest standard surface to displace with other molecules. | Gold, silver, platinum | See products | Learn more | |
Aminated (BPEI) | Covalently bound. Conjugatable surface. | Gold, silver | See products | Learn more | |
Carbonate | For biocojugation. Smaller, less complex molecule with a lower affinity to gold nanoparticle surface than citrate. | Gold | See products | Learn more | |
Carboxyl/Lipoic Acid | Covalently bound. Conjugatable surface. | Gold, silver | See products | Learn more | |
Dodecanethiol | Redispersible and stable in non-polar organic solvents. | Gold, silver | See products | Learn more | |
NHS | For quick and easy bioconjugation – no EDC/NHS activation required. | Gold | See products | ||
PEG | Highest stability in aqueous buffers and polar organic solvents. | Gold, silver | See products | Learn more | |
Polystyrene | Hydrophobic surface that allows for dispersion in a wide range of polar organic solvents. | Gold | See products | Learn more | |
PVP | Large polymer surface. Stable in a wide variety of solvents. | Gold, silver, magnetite | See products | Learn more | |
Silica Shell | Greatest solvent compatibility. Preserves plasmonic properties upon deposition. | Gold, silver, silica | See products | Learn more | |
Silica Shell (Aminated) | Conjugatable surface. Greatest solvent compatibility. Preserves plasmonic properties upon deposition. | Gold, silver, silica | See products | Learn more | |
Streptavidin | For convenient bioconjugation of any biotinylated antibody, protein, or oligonucleotide. | Gold | See products | ||
Tannic Acid | Less easily displaced than citrate but stable in more buffers. | Gold | See products | Learn more | |
Do none of these work for you? Request a Custom Surface |
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