Hyperthermia uses heat as a non-chemical treatment for disease. Plasmonic nanoparticles are extremely efficient at absorbing light in the visible/infrared regions of the spectrum and releasing the energy as heat. Many plasmonic photothermal therapies are in clinical trials including treatments for head and neck cancer, light-pigmented hair removal, and acne therapy. A related application that we are actively researching is how to use the photothermal properties of nanoparticles to rapidly thaw frozen embryos and tissue without damage.
Infrared absorbing plasmonic nanoparticles efficiently convert laser light into heat. Gold nanorods, gold nanoshells, and silver nanoplates can all be engineered to efficiently absorb light at target wavelengths (typically, 600 nm – 1100 nm). Magnetic nanoparticles can also be used in hyperthermia applications by heating with radio frequency (RF) fields, and thus have the advantage of much deeper penetration of the heating energy compared with light penetration into the body. Typically, particles are surface functionalized to provide stability and biocompatibility.
NanoComposix has a comprehensive library of plasmonic nanoparticles that can be manufactured under our ISO 13485:2016 and GMP quality system to produce biocompatible, sterile, low-endotoxin materials suitable for clinical trials and supply. Gold nanorods, gold nanoshells, and silver nanoplates are the most common materials used for photothermal applications, and can be coated with silica or PEGylated. The particles can be further functionalized with antibodies to target particles to a region of interest.
Product Line | Description | Available Materials | Available Surfaces | CV | Concentration | Available Dried | Buy | nanoComposix University |
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Guaranteed low endotoxin | Gold, silver, platinum, magnetite | Multiple | < 18% | 1 mg/mL | No | See products | Learn more | |
For bioconjugation (lateral flow assays, etc.) | Gold | Multiple | < 15% | Varies; usually 20 OD | Yes | See products | Learn more | |
Widest combination of materials and surfaces | Gold, silver, silica, platinum, magnetite | Multiple | Varies; usually < 15% | Varies | Yes | See products | Learn more | |
Most monodisperse | Gold | PEG-carboxyl | < 5% | 0.05 mg/mL | No | See products | Learn more | |
Do none of these work for you? Request a Custom Nanomaterial | ||||||||
We also offer a variety of nanoparticle characterization services |
Surface | Charge | Characteristics | Available Materials | Buy | NCX University |
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Bare (Citrate) | Easiest standard surface to displace with other molecules. | Gold, silver, platinum | See products | Learn more | |
Aminated (BPEI) | Covalently bound. Conjugatable surface. | Gold, silver | See products | Learn more | |
Carbonate | For biocojugation. Smaller, less complex molecule with a lower affinity to gold nanoparticle surface than citrate. | Gold | See products | Learn more | |
Carboxyl/Lipoic Acid | Covalently bound. Conjugatable surface. | Gold, silver | See products | Learn more | |
Dodecanethiol | Redispersible and stable in non-polar organic solvents. | Gold, silver | See products | Learn more | |
NHS | For quick and easy bioconjugation – no EDC/NHS activation required. | Gold | See products | ||
PEG | Highest stability in aqueous buffers and polar organic solvents. | Gold, silver | See products | Learn more | |
Polystyrene | Hydrophobic surface that allows for dispersion in a wide range of polar organic solvents. | Gold | See products | Learn more | |
PVP | Large polymer surface. Stable in a wide variety of solvents. | Gold, silver, magnetite | See products | Learn more | |
Silica Shell | Greatest solvent compatibility. Preserves plasmonic properties upon deposition. | Gold, silver, silica | See products | Learn more | |
Silica Shell (Aminated) | Conjugatable surface. Greatest solvent compatibility. Preserves plasmonic properties upon deposition. | Gold, silver, silica | See products | Learn more | |
Streptavidin | For convenient bioconjugation of any biotinylated antibody, protein, or oligonucleotide. | Gold | See products | ||
Tannic Acid | Less easily displaced than citrate but stable in more buffers. | Gold | See products | Learn more | |
Do none of these work for you? Request a Custom Surface |