Gold Nanoparticles in Solution
Gold nanoparticles for applications in diagnostics, biomedical therapies, and plasmonics.
- TEM, UV-Vis, and DLS data provided with every batch
- Unagglomerated and monodisperse
- Sizes ranging from 5-100 nm with CVs of <15%
- Available with citrate, tannic acid, PVP, lipoic acid, PEG, BPEI, and silica surface functionalizations
These sizes are just our standard products – please contact us if you would like to request a custom size or surface.
N NanoXact, 0.05 mg/mL. Narrow size distribution, wide variety of surfaces.
D NanoXact, dried. Available only with PVP.
B BioPure, 1 mg/mL. Purified and concentrated NanoXact. Sterile and endotoxin-free.
E Econix, 5 mg/mL. Larger quantities, lower cost.
D Econix, dried. Available only with PVP.
U Ultra Uniform, 0.05 mg/mL. Our most monodisperse nanoparticles ever!
Gold Nanoparticle Applications
Gold nanopaticles are readily conjugated to antibodies and other proteins due to the affinity of sulfhydyl (-SH) groups for the gold surface, and gold-biomolecule conjugates have been widely incorporated into diagnostic applications, where their bright red color is used in home and point-of-care tests such as lateral flow assays.
Gold nanomaterials can be conjugated to biomolecules to specifically target cancer cells, and used for photothermal cancer therapy, where their tunable optical properties cause them to convert laser light into heat and selectively kill cancerous cells.
Gold nanoparticles have unique optical properties because they support surface plasmons. At specific wavelengths of light the surface plasmons are driven into resonance and strongly absorb or scatter incident light. This effect is so strong that it allows for individual nanoparticles as small as 30 nm in diameter to be imaged using a conventional dark field microscope. This strong coupling of metal nanostructures with light is the basis for the new field of plasmonics. Applications of plasmonic gold nanoparticles include biomedical labels, sensors, and detectors. The gold plasmon resonance is also the basis for enhanced spectroscopy techniques such as Surface Enhanced Raman Spectroscopy (SERS) and Surface Enhanced Fluoressence Spectroscopy which can be used to detect analytes with ultrahigh sensitivity.
Ultra Uniform Gold Nanospheres
Our standard Au nanospheres have a variety of useful surface chemistries and narrow size distributions (CV < 15%), appropriate for a variety of applications ranging from lateral flow assays to optical coatings. Some applications, however, such as multiplexed dark field labeling or standards for nanoparticle size and shape, require even tighter tolerances on shape and size dispersity. For these applications, nanoComposix has successfully manufactured ultra-uniform, monodisperse gold nanospheres with sizes tunable from 10 nm up to 200 nm. As shown below, these gold nanoparticles have a nearly perfect spherical shape, smooth surfaces, and impressively narrow size distributions (CV < 6%, and for many sizes CV < 4%).
Optical and Scattering Properties
Due to their high uniformity in size and shape, these Au nanospheres scatter a single color of light under dark field microscope imaging (shown below). The high purity of their light scattering signatures makes these nanospheres perfect scattering labels for imaging and building blocks for plasmonic nanostructures and devices.
The gold nanospheres are stabilized with citrate in an aqueous solution. With their stable, easily displaceable surface chemistry, the gold nanospheres can be readily functionalized with a wide variety of molecules, including polymers and small molecules with desired functional groups, inorganic coatings such as silica, and biomolecules including DNA and antibodies for your application.