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❮ Silica

Mesoporous Silica

Like sponges, mesoporous silica nanoparticles (MSN) are able to adsorb a large amount of molecules dissolved in solution thanks to their high surface area; 5 g of mesoporous silica nanoparticles possess the same surface area as an American football field. This high porosity can be controlled and it is possible to synthesize MSN with a particular pore size. This narrow pore size distribution can lead to nanoparticles that will adsorb in their cavity molecules within a specific size range, like advanced nanosponges. Their field of application ranges from catalysis to biomedicine where they are widely used as drug delivery system. Their high surface area, easy surface modification and biocompatibility make them the material of choice for targeted delivery of active pharmaceutical ingredients for cancer therapy among others.

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Mesoporous 100 nm silica, radial pore structure

Monodisperse 100 nm mesoporous silica nanoparticles with radial pore structure can be used for the preparation of high quality and highly reproducible drug delivery systems (DDS) based on silica. The 100 nm size is considered to be ideal in order to evade the reticuloendothelial system (RES) and increase the blood circulation of the particles, this feature is particularly appreciated when targeting specific organs is of importance; these long circulating particles can also take advantage of the large fenestration of blood vessels around tumor for passive targeting of tumors.

Mesoporous 50 nm silica, radial pore structure 

Monodisperse 50 nm mesoporous silica nanoparticles with radial pore structure can be used for the preparation of high quality and highly reproducible drug delivery systems (DDS) based on silica. The 50 nm size can represent an interesting feature for scientists looking for smaller sizes particles with low polydispersity. The applications of these particles are similar to the 100 nm monodispersed mesoporous silica.

Mesoporous 100 nm silica, hexagonal (MCM-41 type) pore structure

MCM-41 type mesoporous silica nanoparticles are the gold standard of the DDS based on silica. They are widely used and most of the current research rely on these type of particles. They present the advantage of having open pores on both end which allows better encapsulation/release of drug (when used as a drug delivery system)


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