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❮ Back to Lateral Flow Immunochromatographic Assays
Gold Nanoshells can deliver 6–20× greater sensitivity in lateral flow assays compared to 40 nm diameter gold colloid. Nanoshells are plasmonic reporter nanoparticles consisting of a silica core coated with a thin (~15 nm) shell of gold. They are available in a 150 nm size for covalent conjugation. nanoComposix also offers traditional 40 nm and 80 nm gold nanospheres, with options for passive and covalent conjugation.
Gold Nanoshells have been integrated into dozens of lateral flow assay systems, offering a clear advantage in stability, reproducibility, dynamic range, and sensitivity.
Nanoshells were utilized in a hormone detection assay where 150 nm gold nanoshells achieved an 8× lower limit of detection compared to 40 nm gold which was necessary to measure the clinically relevant range. A 510k application is under review by the FDA.
A salivary cortisol assay was developed both with 40 nm gold nanospheres and 150 nm diameter Nanoshells. This is a semi-quantitative competition assay where a large dynamic range is required to track diurnal baselines and cortisol spikes. Both the 40 nm nanospheres and the Nanoshells could detect the lowest clinically relevant range of 0.5 ng/mL; use of gold nanoshells increased the dynamic range by a factor of 10.
A 10× increase in sensitivity was obtained when measuring Troponin I analyte in serum using gold Nanoshells compared to 40 nm gold.
An 8× increase in sensitivity was achieved using gold Nanoshells in a malaria test developed by a partner.
Commercially available COVID antigen test
nanoComposix COVID antigen test with 150 nm Nanoshells
Comparison of test line intensity for 7 positives samples when run on a commercially available COVID antigen test using traditional colloidal gold particles versus a nanoComposix COVID antigen test using 150 nm Nanoshells.
