Custom Conjugate Development & Manufacturing
Transform nanoparticles and magnetic beads into application-ready reagents with custom conjugation, antibody functionalization, process optimization, and scalable manufacturing.
Whether you are developing a diagnostic assay, nanomedicine, or specialized research reagent, our scientists partner with you to optimize conjugation chemistry, maximize reproducibility, and scale manufacturing from feasibility through commercial production.
Supporting Your Application
Life Science Research
- Cell separation
- Protein purification
- Flow cytometry
Diagnostics
- LFA
- ELISA
- Biosensors
Nanomedicine
- Targeted delivery
- Imaging
From Particle to Application-Ready Reagent
Successful conjugates require more than simply attaching a biomolecule. Surface chemistry, conjugation strategy, purification, and process optimization all influence stability, functionality, and reproducibility.
Our team develops custom conjugates tailored to your application using well-characterized particle platforms and scalable manufacturing processes.
Choose the Right Particle Platform
Magnetic Beads
Flexible platforms for antibody functionalization, target capture, immunoassays, bioseparation, and sample preparation.
Gold Nanoparticles & Nanoshells
BioReady products for antibody conjugation, lateral flow assays, and biosensors. Low-endotoxin options for nanomedicine and photothermal applications.
Silica Nanoparticles & Microparticles
Customizable particles for imaging, sensing, and nanomedicine applications. Mesoporous silica platforms for advanced delivery applications.
Iron Oxide Nanoparticles
Superparamagnetic iron oxide nanoparticles (SPIONs) for biosensing, targeted delivery, and magnetic resonance imaging (MRI) research.
Optimize Your Conjugation Strategy
Our scientists develop custom conjugates with a range of proven chemistries to functionalize nanoparticles and magnetic beads with antibodies, enzymes, nucleic acids, peptides, and other biomolecules. We work with you to select the conjugation strategy that best balances functionality, reproducibility, and manufacturability for your application.
Common Conjugation Strategies
Covalent
EDC/sulfo-NHS, click chemistry, and thiol coupling
Affinity
Streptavidin-biotin, Protein A, and Protein G
Passive
Optimized for select gold nanoparticle platforms
Build Application-Ready Reagents
From concept to manufacturing, we transform particles into application-ready reagents that accelerate development and enable your innovation.
Select the development program that best fits your project, from proof-of-concept studies to scalable manufacturing.
 NanoFab Packages |
 NanoFab Mini |
 NanoFab QuickStart |
 NanoFab Pro |
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| Best Fit | Custom conjugate feasibility from catalog particle & bead platforms |  |
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| Conjugate optimization & custom conjugation chemistries | |
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| Process development & scale-up | |
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| Pricing | Starting at | $6,000 | $15,000 | $40,000 |
Let’s Solve Your Conjugation Challenges
Every application presents unique technical challenges. Our scientists work alongside your team to develop functionalized particles that deliver the performance, reproducibility, and scalability your project requires.
FAQs: Custom Conjugation and Development Services
What types of biomolecules can nanoComposix conjugate to particles?
We can develop functionalized nanoparticles and magnetic beads using antibodies, enzymes, nucleic acids, and other biomolecules. The conjugation strategy is selected based on the particle platform, biomolecule, application, and required manufacturing scale.
Can you develop antibody-functionalized magnetic beads?
Yes. Magnetic beads can be functionalized with antibodies for target capture, immunoassays, cell separation, protein purification, bioseparation, and sample preparation. Development may include surface activation, antibody coupling, purification, blocking, stability evaluation, and scale-up.
What click chemistry options do you offer?
We offer copper-free click chemistry options for biomolecule conjugation, including DBCO–azide and tetrazine–TCO coupling. The appropriate chemistry is selected based on the particle platform, biomolecule, reaction conditions, and application requirements.
Can a custom conjugation project begin with a catalog particle?
Yes. Catalog particles and magnetic bead platforms can provide a well-characterized starting point for feasibility studies. A NanoFab Mini project can be used to evaluate custom conjugate feasibility using an existing particle or bead platform before moving into broader optimization or process development.
Can you support conjugate development for lateral flow assays and other diagnostics?
Yes. We support antibody conjugation and functionalized particle development for lateral flow assays, ELISA, biosensors, immunoassays, target capture, and other diagnostic applications. Development can include particle selection, conjugation optimization, purification, stability assessment, and manufacturing scale-up.
Explore nanoparticles for precision diagnostics
Do you offer conjugation kits and protocols for internal feasibility work?
Yes. BioReady conjugation kits and conjugation protocols are available for teams that want to perform initial passive or covalent conjugation work internally. Custom development services are available when you need direct scientific support, specialized chemistry, process optimization, or scalable manufacturing.
How are custom conjugates characterized?
Characterization is selected based on the particle platform and intended application. Evaluation may include particle size and distribution, surface charge, optical properties, concentration, conjugation efficiency, biomolecule content, colloidal stability, and functional performance.
Learn more about our Characterization Services
Can you develop functionalized particles for nanomedicine applications?
Yes. Custom conjugation and antibody functionalization can support targeted delivery, imaging, biosensing, and other nanomedicine applications. The development approach is tailored to the particle platform, targeting ligand, biological environment, performance requirements, and future manufacturing needs.
Learn more about our Nanomedicine CDMO services
Can nanoComposix scale a conjugation process from feasibility through manufacturing?
Yes. NanoFab programs can support progression from initial feasibility through conjugate optimization, process development, reproducibility studies, and manufacturing scale-up. The appropriate package depends on whether you need a catalog-based feasibility study, custom chemistry optimization, or a scalable manufacturing process.
Contact our team to discuss the appropriate development path