At nanoComposix, we help clients develop innovative and practical solutions for the fabrication of precisely engineered nanomaterials. Collaboration is a key driver in technology development and by openly sharing data and results with our clients, we can rapidly solve fabrication and integration challenges. Our multidisciplinary team of scientists and engineers brings decades of nanofabrication and processing expertise to projects and helps our clients accelerate their commercial development.
Click a section below to learn more about case studies for each application.
Cardiovascular Disease Treatment
Gold nanoparticles were coated with the client’s proprietary biologic to target and treat cardiovascular disease. The gold nanoparticle cores served as both a biocompatible scaffold and a means to track the pharmacokinetics of the platform. nanoComposix completed a technology transfer of the client’s existing analytical methods and processes, successfully scaled the procedure from a milliliter to a liter scale for future manufacturing, and optimized the lyophilization and storage conditions of the therapeutic.
Nanoparticles for Immunotherapy
nanoComposix engaged in close collaboration with a client to comprehensively develop and manufacture a cutting-edge PLGA nanoparticle-based immunotherapy. Work began by successfully integrating the client’s API into a nanoparticle tailored to the unique requirements of the therapy and progressed through scale-up, process development, transfer to manufacturing, and the production of GMP material for Phase I and Phase II clinical trials.
Antibacterial Silver Nanoparticles for Use in a Wound Dressing
A physician client treating patients with diabetic wounds contacted nanoComposix to manufacture silver particles to be used on the surface of a wound compression dressings. The resulting product was utilized in a medical case study for the treatment of wounds and diabetic ulcers.
Photothermal Nanoparticle for Hair Removal
nanoComposix assisted in the development and manufacture of a photothermal hair removal treatment for Sienna Biopharmaceuticals. This topical therapeutic utilized silica-shelled silver nanoplates that were developed and optimized by nanoComposix, first under R&D controls and later under the NCX Quality Management System. During the R&D phase, nanoComposix developed a process to fabricate and encapsulate nanoplates for prototyping and proof of concept demonstration in pilot studies.
Technical Transfer of a GMP Topical Photothermal Therapeutic
A client required a second source for a topical acne therapeutic with a nanoparticle component. A Manufacturing Master Record (MMR) and Manufacturing Batch Records (MBRs) were provided to nanoComposix for all intermediates, and the synthesis of the nanoparticle component was successfully replicated at nanoComposix. Engineering runs were performed using draft batch records while additional test methods were developed and validated as required. nanoComposix led qualification of all raw material suppliers. qualification. A cGMP-compliant qualification batch and commercial GMP lots were produced and delivered to the client.
Targeted Silica-coated Iron Oxide Nanoparticles for in-vivo Delivery to Tumors
Magnetite nanoparticles with a silica shell were designed by nanoComposix and functionalized with a humanized anti-prostate-specific membrane antigen using a covalent binding strategy for cell-specific targeting. Non-specific binding was minimized via the development of a mixed monolayer of polyethylene glycol molecules at the particle surface. Feasibility testing showed these nanoparticles were extremely stable and had excellent specific targeting ability. In-vivo data showed targeted delivery and tumor reduction when the magnetic nanoparticles were heated via an applied alternating magnetic field.
Development to GMP Manufacture of a Mesoporous Silica Based Cancer Therapeutic
A pharmaceutical company approached nanoComposix to develop mesoporous silica particles as a key component in their cancer immunotherapy. Feasibility testing of several variants was completed to identify the key material properties and specifications needed to enhance the immunotherapy. Development progressed to scale-up efforts, and nanoComposix developed processes to scale the manufacture this material 1000-fold.
Development of an Oligonucleotide Conjugated Gold Nanoparticle Cancer Therapeutic
The sponsor of an oligonucleotide drug candidate contracted nanoComposix for the development of a custom gold nanoparticle conjugate. nanoComposix designed, optimized, and characterized this formulation for enhanced binding and developed a companion lateral flow immunoassay to quickly and easily test the functionality of these particles prior to in-vitro or in-vivo testing. nanoComposix provided the sponsor with complete characterization including TEM visualization, UV-Visspectra pre and post conjugation, and stability data.
Drugs & Diagnostics for Tropical Diseases
Drugs & Diagnostics for Tropical Diseases (DDTD), a non-profit organization with a mission to discover new treatments and diagnostics for neglected tropical diseases, developed a LFA for the detection of Loa loa, one of the parasites that cause river blindness. Gold nanoshells were used as the detection particle to increase the assay sensitivity. Learn more.
Bulk Conjugate Supply for Infectious Disease Rapid Diagnostic
To support the development and commercial release of a rapid point-of-care diagnostic for SARS-COV-2, the client required a supply of high-sensitivity custom gold conjugates at scale. nanoComposix developed and scaled a custom process to produce antibody-nanoshell conjugates, meeting the required sensitivity targets and production scale. Client’s assay has received approval for use in Australia with additional approvals pending.
Sensitivity Enhancement of Food Safety Assay Using Gold Nanoshells
To maintain their leadership position, the client needed to improve the sensitivity of their assays and enable a higher degree of multiplexing. The client evaluated multiple reporter particles and detection platforms without success prior to contacting nanoComposix. Using gold nanoshells from nanoComposix, the client was able to achieve the required sensitivity and multiplexing performance and maintain their market leadership.
Silver Nanoparticle Reference Material With Multi-year Shelf Life
In collaboration with NIST scientists, a dried silver nanoparticle formulation was developed that can be re-dispersed without any aggregation. Tests have shown that the silver nanoparticles have a multi-year shelf life. Material for over 1000 reference material samples was delivered.
Self Healing Composites for Cryogenic Applications
Nanoenabled composites structures with high thermal and electrical conductivity in a self-healing polymer matrix were designed and tested under cryogenic cycling conditions. The nanoparticles additives increased performance at very low loading densities.
Plasmonic Materials for Increasing Efficiency of Solar Cells
Plasmonic nanoparticles with high scattering coefficients were integrated into solar panels to increase the efficiency of thin film solar cells. A surface functionalization and deposition method was developed to ensure homogeneous coatings over large surface areas.
Silver Nanoparticles for Antimicrobial Water Filtration
Designed a high surface area substrate containing silver nanoparticles for long term antimicrobial protection of water filtration units used in Africa.
Highly Compressed Aerosolizable Nanopowders
A high extinction anisotropic nanopowder was compression packed in a grenade format to produce an obscuration device that rapidly creates a visible and infrared blocking cloud for personnel and vehicle protection.
Non-fading Plasmonic Coatings for Mobile Devices
Developed methods to uniformly distribute non-fading plasmonic materials onto a polycarbonate substrate for consumer electronics applications. Film color and uniformity were homogeneous and colors did not fade even after extended exposure to intense UV light.
Why Choose nanoComposix?
Scientific Rigor
We select performance metrics based on the requirements of the final product, and identify the critical parameters for the development of high yield, scalable and reproducible manufacturing and processing methods.
Full Disclosure
Interested in seeing weekly or monthly summaries of our data and results? We provide written reports, access to lab notebooks, and regular conference calls to answer questions and collaboratively make strategic decisions about the project direction.
Innovation
Our interdisciplinary team has a proven history of developing innovative solutions to tough problems and delivering cost-effective solutions that exceeds our customer's expectations.
Confidentiality
Our partnership, as well as all work and data associated with the R&D effort, will remain fully confidential.
Whether you work for a government agency, non-profit foundation, academic institution, or commercial business, the nanoComposix team can help you.