Explore how development teams have worked with nanoComposix to solve nanoparticle formulation, scale-up, conjugation, technology transfer, manufacturing, and materials integration challenges. These case studies span programs from early feasibility through commercial and GMP manufacturing.
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Nanomedicine, Therapeutics & Aesthetics
Examples spanning drug delivery, therapeutic nanoparticles, medical devices, formulation development, scale-up, technology transfer, and GMP manufacturing.
Gold Nanoparticles for Cardiovascular Therapy
A client needed gold nanoparticles coated with a proprietary biologic for a cardiovascular therapeutic platform. nanoComposix transferred the existing analytical methods and process, scaled production from milliliter to liter volumes, and optimized lyophilization and storage conditions.
Capabilities: Bioconjugation · Technology transfer · Scale-up · Lyophilization
PLGA Nanoparticles for Immunotherapy
A therapeutic program required integration of a client API into a PLGA nanoparticle formulation. Development progressed through formulation optimization, process development, scale-up, manufacturing transfer, and production of GMP material for Phase I and Phase II clinical trials.
Capabilities: PLGA formulation · Process development · Scale-up · GMP manufacturing
Silver Nanoparticles for a Wound Dressing
A physician developing a wound-care application needed silver nanoparticles for integration onto a compression dressing. nanoComposix manufactured the particles used in the resulting medical case study involving wounds and diabetic ulcers.
Capabilities: Silver nanoparticles · Medical device integration
Photothermal Nanoparticles for Hair Removal
nanoComposix supported development and manufacturing of silica-shelled silver nanoplates for a topical photothermal treatment. Work included particle development, encapsulation, process optimization, prototype production, and materials for pilot studies.
Capabilities: Plasmonic nanoparticles · Encapsulation · Process development
Second-Source Transfer of a Topical Nanoparticle Therapeutic
A client needed a second manufacturing source for a topical therapeutic containing a nanoparticle component. nanoComposix replicated the supplied manufacturing process, completed engineering runs, developed additional test methods as required, qualified raw-material suppliers, and produced qualification and commercial GMP batches.
Capabilities: Technology transfer · Second sourcing · Process development · GMP manufacturing
Targeted Silica-Coated Iron Oxide Nanoparticles
Silica-coated magnetite nanoparticles were functionalized with a humanized anti-prostate-specific membrane antigen using a covalent conjugation strategy. A mixed PEG surface was developed to reduce nonspecific binding while maintaining specific targeting.
Capabilities: Magnetic nanoparticles · Surface chemistry · Antibody conjugation
Mesoporous Silica Therapeutic Development & Scale-Up
A pharmaceutical company needed mesoporous silica particles as a component of a cancer immunotherapy. Feasibility studies evaluated multiple variants to establish critical material properties and specifications, followed by process development that increased manufacturing scale approximately 1,000-fold.
Capabilities: Mesoporous silica · Feasibility · Process development · Scale-up
Oligonucleotide-Conjugated Gold Nanoparticles
A therapeutic developer needed a custom gold nanoparticle conjugate for an oligonucleotide drug candidate. nanoComposix designed and optimized the formulation, developed a companion lateral flow assay for functional testing, and characterized the conjugate using TEM, UV-Vis, and stability measurements.
Capabilities: Gold conjugation · Assay development · Characterization
Diagnostics
Examples of nanoparticle reporter selection, assay sensitivity improvement, custom conjugation, and scaled supply for diagnostic applications.
Gold Nanoshells for a Tropical Disease Lateral Flow Assay
Drugs & Diagnostics for Tropical Diseases developed a lateral flow assay for detection of Loa loa. Gold nanoshells were selected as the reporter particle to increase assay sensitivity.
Capabilities: Lateral flow · Gold nanoshells · Reporter optimization
Scaled Gold Conjugate Supply for a Rapid Diagnostic
A diagnostic developer needed high-sensitivity custom gold conjugates at commercial scale for a rapid point-of-care infectious disease assay. nanoComposix developed and scaled an antibody-nanoshell conjugation process that met the required sensitivity and production-volume requirements.
Capabilities: Custom conjugation · Process scale-up · Manufacturing
Improved Sensitivity for a Food Safety Assay
A diagnostic developer needed greater assay sensitivity and multiplexing capability after evaluating multiple reporter particles and detection platforms. Gold nanoshells provided the sensitivity and multiplexing performance required for the application.
Capabilities: Gold nanoshells · Reporter selection · Sensitivity · Multiplexing
Optical & Advanced Materials
Examples of reference materials, optical coatings, composite integration, antimicrobial surfaces, and engineered nanoparticle systems.
Silver Nanoparticle Reference Material with Multi-Year Shelf Life
In collaboration with NIST scientists, a dried silver nanoparticle formulation was developed that could be redispersed without aggregation. Material for more than 1,000 reference-material samples was produced and delivered.
Capabilities: Reference materials · Formulation · Stability · Scale-up
Self-Healing Nanocomposites for Cryogenic Applications
Nano-enabled composite structures were developed using conductive nanoparticle additives in a self-healing polymer matrix and evaluated under cryogenic cycling conditions. The nanoparticle additives increased performance at low loading levels.
Capabilities: Nanocomposites · Materials integration · Cryogenic testing
Plasmonic Materials for Thin-Film Solar Cells
Plasmonic nanoparticles with high scattering coefficients were integrated into thin-film solar cells. nanoComposix developed surface-functionalization and deposition approaches to produce homogeneous nanoparticle coatings across large surface areas.
Capabilities: Optical engineering · Surface functionalization · Coatings
Silver Nanoparticles for Antimicrobial Water Filtration
A high-surface-area substrate incorporating silver nanoparticles was developed for long-term antimicrobial protection in water-filtration systems used in Africa.
Capabilities: Silver nanoparticles · Surface integration · Applied materials
High-Extinction Aerosolizable Nanopowders
A high-extinction anisotropic nanopowder was developed and processed into a compressed format designed to rapidly generate visible- and infrared-blocking aerosol clouds.
Capabilities: Optical materials · Particle engineering · Powder processing
Non-Fading Plasmonic Coatings for Consumer Electronics
nanoComposix developed a method for uniformly distributing plasmonic materials onto polycarbonate substrates. The resulting films provided homogeneous color and maintained their appearance after extended exposure to intense UV light.
Capabilities: Plasmonic materials · Coatings · Materials integration
What You Can Expect from a Development Program
Requirements-Driven Development
We define the material properties and performance metrics that matter to the intended application, then use them to guide formulation, process development, and characterization.
Transparent Technical Collaboration
Projects can include written reports, laboratory data, regular technical discussions, and collaborative decisions as results guide the next stage of development.
Scale-Up with Manufacturing in Mind
Development programs consider yield, reproducibility, processing requirements, and scale so promising feasibility results can progress toward practical manufacturing.
Confidentiality
Client projects, data, and development work are treated as confidential throughout the collaboration.
Looking for a development partner for your nanoparticle program?
Whether you need to establish feasibility, improve an existing formulation, transfer a process, or scale toward manufacturing, our technical team can help define the next step.
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