Inductively coupled plasma mass spectrometry (ICP-MS) is a sensitive analytical technique used to identify and quantify the elemental composition of samples, including metals and select nonmetals with atomic masses from 7-250. Samples at nanoComposix are analyzed with a Thermo X-Series II ICP-MS equipped with Collision Cell Technology for advanced interference removal.
To measure total metal concentration, samples are digested in acid with the appropriate matrix suitable to stabilize a dissolved sample. For ionic samples, simple dilution and matrix matching is the only sample preparation required. For samples that are tougher to dissolve, we can use a CEM MARS 6 microwave-assisted reaction system (at additional cost) to ensure complete dissolution.
To measure the free ion concentration in a solution of nanoparticles, the nanoparticles are first separated from the suspension solution using a low-molecular weight centrifugal filter and the resulting supernatant is analyzed. Ionic content is particularly important for colloidal chemistry, especially in silver nanoparticles or nanoparticle reactions that do not go to completion and leave unreacted precursor behind.
Our ICP-MS service can detect and quantify the following metals with high confidence: Al, Ca, Ti, Cr, Fe, Co, Cu, Zn, Se, Mo, Rh, Ag, Cd, W, Pt, Au, Pb. Certain analytes can be detected to levels as low as parts per trillion. Detection of additional elements available upon request.