Dynamic Light Scattering (DLS) Nanoparticle Analysis
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Dynamic Light Scattering (DLS) measures the diffusion of nanoparticles in solution and computes the hydrodynamic diameter using knowledge of the solvent properties and the Stokes-Einstein relationship. DLS rapidly provides information on the size and aggregation state of nanoparticles in solution.
At nanoComposix, DLS measurements are performed on Malvern Zetasizer Nano ZS instruments equipped with a HeNe laser operating at 633 nm and a back-scattering detector at 173 degrees.
Sample Concentration Chart
| Particle size | Min. Concentration (Recommended) | Max. Concentration (Recommended) |
|---|---|---|
| < 10 nm | 0.5 g/l | Only limited by the sample material interaction, aggregation, gelation etc. |
| 10 nm to 100 nm | 0.1 mg/l | 5% mass (assuming a density of 1g/cm3) |
| 100 nm to 1 µm | 0.01 g/l (10–3 % mass) | 1% mass (assuming a density of 1 g/cm3) |
| > 1 um | 0.1 g/l (10–2 % mass) | 1% mass (assuming a density of 1 g/cm3) |
* Table taken from the manuals for Zetasizer Pro, Ultra, and Nano ZS series. Modeled on Polystyrene Latex (1 g/cm3) and will scale proportionally with nanomaterial density.