Surface plasmon resonance (SPR) is a highly sensitive tool capable of label-free monitoring of biomolecular interactions in real-time. This application note delves into the fundamental science of colloidal nanoparticles and localized surface plasmon resonance (LSPR). It presents data illustrating how nanoparticle sensitivity to their local environment depends on particle size and geometry. We systematically evaluate the refractive index sensitivity (RIS) of gold nanospheres, nanoshells, and nanorods, and demonstrate a proof-of-concept SPR biosensor capable of monitoring protein interactions with the particle surface.
Monitoring Biomolecular Interactions via Local Surface Plasmon Resonance Sensing
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