Surface plasmon resonance (SPR) is a highly sensitive tool capable of label-free monitoring of biomolecular interactions in real-time. Here, we systematically evaluated the refractive index sensitivity (RIS) of nanoComposix gold nanospheres, nanoshells, and nanorods, and demonstrate the refractive index sensitivity increases with size for spheres and aspect ratio for nanorods. We then integrated these nanoparticles into a proof-of-concept SPR biosensor for protein detection, demonstrating that nanoparticles with a higher RIS directly increase SPR assay sensitivity.
Monitoring Biomolecular Interactions via LSPR
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