Nanoparticles for Precision Diagnostics
Reproducible nanoparticles designed for conjugation to antibodies, proteins, and nucleic acids. High-quality materials to support assay sensitivity, reproducibility, and streamlined integration.
Contact UsBioReady Nanoparticles – Built for your Diagnostic
Improve Diagnostic Assay Performance with Engineered Nanoparticles
Diagnostics depend on signal quality, reproducibility, and manufacturing consistency. nanoComposix nanoparticles are engineered to help you achieve all three critical elements.
Strong Optical Signal for Increased Sensitivity
Precisely engineered gold nanoparticles increase sensitivity in sandwich and competitive assay formats.
Consistent Size & Shape for Assay Reproducibility
Tight particle size and shape distributions reduce variability, enabling reliable conjugation while delivering consistent assay performance across lots.
Optimized Surfaces for Efficient Bioconpatible Conjugation
Engineered surface chemistries support reproducible conjugation efficiency, accelerating development and decreasing scrap rates.
Colloidal Suspension for Microfluidics
Colloidal nanoparticles stay in suspension longer, support magnetic mixing, and can also be removed magnetically to isolate biomolecules. This gives your team unprecedented flexibility to design cartridges and simplify workflows.
Stability for Shelf-Life & Manufacturing
Well-characterized surfaces and robust processes support long-term stability during kitting, storage and transport, and assay integration. Manufactured in the USA.
Improve sensitivity and confidence in food testing assays with nanoparticles designed to enhance signal generation and improve lot-to-lot consistency.
Case Study: A point-of-care food safety test developer needed to improve assay sensitivity to retain a key customer in a highly competitive market. Through close collaboration with nanoComposix experts, the team evaluated and implemented optimized gold nanoshells and 80 nm gold colloid to meet stringent detection and scale requirements. These improvements enabled successful commercialization of the assay, allowing the customer to retain their client and maintain a leadership position in high-performance food safety testing.
Enable consistent antigen detection and reliable performance in rapid tests, lateral flow assays, and IVD platforms.
Case Study: A diagnostics company developing a rapid SARS-CoV-2 point-of-care test needed high-sensitivity gold conjugates at commercial scale. A custom antibody–nanoshell conjugation process developed at nanoComposix met sensitivity and production requirements, enabling regulatory approval with additional approvals pending.
Support rugged, point-of-care diagnostic formats that require fast readouts and dependable performance in field settings.
Case Study: A leading animal health company struggled with false positives and reliability issues from in-house nanoparticle conjugate production. Transitioning to off-the-shelf streptavidin-gold conjugates eliminated false positives, streamlined production, and supported continued leadership in veterinary diagnostics.
Leverage plasmonic, magnetic, and optical properties to enhance imaging-based diagnostics, biosensing, and next-generation assay technologies.
Case Study: A diagnostics company’s imaging-based platform required a particle with precise optical properties, efficient magnetic separation, and an optimized surface for antibody conjugation. Tailored magnetic gold nanoshells enabled improved sensitivity and accuracy, assay speed, and scalable production.
Diagnostic Particle Catalog
Find the right nanoparticle for passive adsorption, covalent conjugation, or affinity-based bioconjugation in our BioReady catalog:
| Particle & Surfaces | Key Advantage |
|---|---|
|
10 nm Gold Carboxyl |
High surface area for dense, covalent protein attachment with minimal steric interference. ★ Best for: Surface plasmon resonance (SPR) biosensors |
|
13 nm Gold Bare (Citrate) |
Gold standard for spherical nucleic acid therapeutics and diagnostics. ★ Best for: Nucleic acid-based therapeutics & biosensors |
|
20 nm Gold Bare, Carboxyl, Streptavidin |
Versatile platform for biosensors and LFAs. High surface area enables increased antibody loading for detecting high analyte concentrations. ★ Best for: Biosensors, Point-of-Care assays |
|
40 nm Gold Bare, Carboxyl, Streptavidin |
Recommended starting point for diagnostic assay development, including lateral flow assays and next-generation biosensors. Streptavidin conjugates support rapid multiplexing across assay formats. ★ Best for: Point-of-Care assays, biosensors |
|
80 nm Gold Bare, Carboxyl |
Increased visual signal for improved sensitivity in lateral flow assays while maintaining the classic red color. ★ Best for: High-sensitivity LFAs |
|
150 nm Gold Nanoshells Bare, Carboxyl, Streptavidin |
High sensitivity in sandwich assays with blue-green color readout. ★ Best for: Next-generation LFA, advanced optical biosensing strategies |
|
200 nm Magnetic Gold Nanoshells Carboxyl |
Optical sensitivity of gold nanoshells combined with rapid magnetic manipulation. Enables enrichment and enhanced detection in integrated workflows. ★ Best for: Integrated magnetic–optical workflows |
|
20 nm Magnetic Iron Oxide Carboxyl, Streptavidin |
Superparamagnetic for efficient biomolecule capture, separation, and concentration. ★ Best for: Immunomagnetic assays, upstream diagnostic workflows |
Table 1: Overview of key advantages of nanoparticles from the nanoComposix catalog for diagnostic applications
Which particle is right for me?
Building a biosensor?
40 nm gold nanoparticles are a recommended starting point for most biosensors. Smaller gold particles (10–20 nm) provide high surface area for increased protein loading while limiting steric hindrance of the detection particle.
Streptavidin conjugates are popular for rapid and flexible multiplexing.
Developing or scaling an LFA?
40 nm gold is your industry-standard baseline.
For sandwich assays: larger particles, such as 80 nm nanospheres, 150 nm gold nanoshells, or 200 nm magnetic gold nanoshells, can further improve sensitivity.
For competitive assays: smaller particles, such as 20 nm gold nanospheres may enhance sensitivity.
Need enrichment or workflow control?
Magnetic gold or iron oxide nanoparticles add separation, concentration, and automation. Surface chemistries compatible with standard bioconjugation strategies enable integration into diagnostic workflows.
Don’t see what you’re looking for? nanoComposix supports custom nanoparticle development for diagnostic programs requiring specialized performance.
Why Diagnostic Developers Choose nanoComposix
Reliable Nanoparticle Quality from Lab to Production
Controlled synthesis delivers tight size and shape uniformity across production lots. Batch sizes up to 2000 L at 1 OD and 100 L at 20 OD support consistent material inputs from development through manufacturing.
Figure 1: 40 nm nanoparticle batch-to-batch reproducibility supports reliable assay outcomes
Benchmarking Nanoparticle Uniformity
Comparative evaluations against other commercial suppliers show consistent nanoparticle uniformity for nanoComposix materials, supporting reproducible workflows across diagnostic development programs.
Figure 2: Comparison of nanoComposix 40 nm BioReady colloidal gold against three other leading suppliers
Expert Support from Selection to Scale
Our nanoparticle scientists work directly with your team to optimize assay development, conjugation, and manufacturing requirements for diagnostic applications. Our expertise can help you with both off-the-shelf and custom nanoparticles.
Quality You Can Count On
Reduce risk and streamline workflows with our high-quality, aggregation-free nanoparticles. ISO 13485 and GMP compliant capabilities are available to support regulated diagnostic workflows.
- ISO 13485 Certificate
- Manufactured in the USA
- BIOSECURE Act Compliant
FAQ: Nanoparticles for Diagnostics
I’m not sure which nanoparticle would be best for my assay. What should I start with?
We typically recommend starting with 40 nm colloidal gold. If this does not meet your application’s needs, try our particle selection app for LFA or contact us.
What are the benefits of 1 OD vs 20 OD gold colloid?
Many diagnostic workflows are built around 1 OD materials, allowing for seamless integration. When efficiency and throughput matter, 20 OD nanoparticles deliver higher particle concentration to streamline processing and scale production.
What is the shelf life of gold nanoparticles?
The shelf life of our BioReady products depends on particle type, surface chemistry, and concentration. Each lot has an expiration date listed on the Certificate of Analysis (CoA). Carboxyl gold nanoparticles are typically stable for up to 3 years from the date of manufacture, while protein-conjugated particles generally have a shelf life of 6 months to 1 year.
Do you have other surface chemistries available?
Our experts have experience with many surface chemistries. Connect with our team to discuss your particle requirements.
I want to switch from my current nanoparticle provider. What programs do you offer that can help me?
Our BioReady nanoparticles are built for seamless workflow integration. We offer multiple lots to support your verification and validation studies as you transition from your current supplier. Contact us to discuss your supply chain needs.
To get started on your journey, our colloidal gold characterization services support your early-stage verification and risk assessment activities for changes to critical assay components.
Where can I find more information about bulk pricing?
We offer bulk nanomaterials – contact us for more information.
Do you provide nanoparticle integration support for assay development and diagnostic workflows?
Yes. Our experts support seamless integration of gold and magnetic nanoparticles into your diagnostic workflow, helping you select the right particle and optimize performance for your application. Connect with our team to discuss your application.
How does BIOSECURE compliance benefit my diagnostic assay?
BIOSECURE compliance helps reduce supply chain risk by ensuring materials and services are sourced in alignment with U.S. national security standards. For diagnostic assay developers, this supports procurement confidence, commercial readiness, and long-term program stability.